The 60-year-old assumed responsibility for his 1,000th match as a chief in Sunday’s 3-2 loss by Tottenham – his main game as Magpies manager under the new proprietors.
Bruce said there had been “highs and lows” and that he trusted the new proprietors could “take the club forward”.
Graeme Jones will take between time charge of the Premier League side.
Newcastle said the arrangement of another administrator “will be reported at the appropriate time”.
The Tyneside club has made a winless beginning to the Premier League prepare and sit second from the base after three draws from their initial eight games.
Bruce was named Magpies administrator in July 2019 and accomplished completions of thirteenth and twelfth in his two full seasons in control.
“I might want to thank my training group, the players, and the care staff specifically for all their diligent effort.
“There have been highs and lows, yet they have given everything even in troublesome minutes and ought to be glad for their endeavors.
“This is a club with unimaginable help and I trust the new proprietors can take it forward to where we as a whole need it to be. I hope everything works out for everybody of karma for the remainder of this season and then some.”
Bruce had a 27.4% success rate from 84 association games at Newcastle, which was the 10th best contrasted with past Magpies chiefs who had been accountable for no less than 20 Premier League matches.
A Newcastle articulation said the club “might want to put on record its appreciation to Steve for his commitment and wishes him well for what’s to come”.
The club’s next game will be at Crystal Palace at 1500 BST on Saturday, 23 October.
In a meeting with the Daily Telegraph, Bruce said: “I figure this may be my last work.
“They have been stressed over me… particularly my better half Jan.
“I’m 60 years of age and I couldn’t say whether I need to put her through it once more. We have a decent life along these lines this will likely be me done as a chief – until I get a call from an executive someplace inquiring as to whether I can give them a hand. Never say never, I’ve discovered that.”
He added: “I needed so seriously to make it work.
“I was so pleased to be chief of Newcastle United, even in obscurity times, still up in the air to continue onward and to keep this club in the Premier League.”
It was consistently Steve Bruce’s amazing line of work to assume responsibility for Newcastle United however he has gotten a great deal of analysis from the allies, a ton of misuse which I realize he feels has gone excessively far now and again.
I think he is a pragmatist. He would have said the takeover from a footballing sense is ideal for Newcastle United Football Club as far as the venture it will without a doubt bring.
I think he is additionally a pragmatist in that he realized that it would most likely imply that they’d need to get their chief and I think in that sense it is what it is.
Indeed he’ll be disillusioned, any administrator loses his employment, yet I think when he reflects there may be a component of help also because of the analysis and misuse that he has gotten, that he’s presently not in the terminating line.
It turned out to be very clear at the end of the week that the allies were not going to endure such a situation for significantly longer, it’s incredibly difficult for any administrator to make due in those kinds of conditions.